Crossroads Guitar Festival — музыкальный фестиваль и благотворительный концерт, впервые проведённый в 2004 году. Фестиваль проводится в пользу основанного Эриком Клэптоном центра лечения наркомании Crossroads Centre. Как и в 2007 году, фестиваль вновь состоялся в Toyota Park в Бриджвью, штат Иллинойс 26 июня 2010 года и стал очередным праздником блюза.

DISC1:
Introduction - Bill Murray
01. Sonny Landreth with Eric Clapton - Promise Land
02. Sonny Landreth - Z Rider
03. Robert Randolph & the Family Band - Traveling Shoes
04. Pino Daniele, Joe Bonamassa, Robert Randolph & The Family Band - Going Down
Robert Cray Introduction - Bill Murray
05. Robert Cray with Jimmie Vaughan & Hubert Sumlin - Killing Floor
06. Jimmie Vaughan with Robert Cray & Hubert Sumlin - Six Stings Down
ZZ Top Introduction - Bill Murray
07. ZZ Top - Waiting For the Bus
08. ZZ Top - Jesus Just Left Chicago
09. Doyle Bramhall II - Gypsy Blood
10. Doyle Bramhall II - In My Time Of Dying (Jesus Make Up My Dying Bed)
11. Gary Clark Jr. - Bright Lights
12. Sheryl Crow with Derek Trucks, Susan Tedeschi, Doyle Bramhall II & Gary Clark Jr. - Long Road Home
13. Sheryl Crow with Eric Clapton, Doyle Bramhall II & Gary Clark Jr. - Our Love Is Fading
14. Bert Jansch - Blackwaterside
15. Stefan Grossman with Keb’ Mo’ - Mississippi Blues
16. Stefan Grossman with Keb’ Mo’ - Roll And Tumble Blues
Vince Gill Intoduction - Bill Murray
17. Vince Gill with Keb’ Mo’, James Burton, Earl Klugh & Albert Lee - One More Last Chance
18. Vince Gill with James Burton, Albert Lee, Keb’ Mo’, Earl Klugh - Mystery Train
19. Vince Gill with Sheryl Crow, Keb’ Mo’, Albert Lee, James Burton, Earl Klugh - Lay Down Sally
20. Earl Klugh - Angelina
21. Earl Klugh - Vonetta
John Mayer Intoduction - Bill Murray
22. John Mayer Trio - Who Did You Think I Was
23. John Mayer Trio - Ain't No Sunshine

DISC2:
Derek Trucks Introduction - Bill Murray
01. Derek Trucks & Susan Tedeschi Band - Midnight In Harlem
02. Derek Trucks & Susan Tedeschi Band with Warren Haynes - Comin' Home
03. Warren Haynes - Soulshine
04. David Hidalgo and Cesar Rojas with Derek Trucks - Don't Keep Me Wondering
05. Derek Trucks & Susan Tedeschi Band with Warren Haynes, David Hidalgo, Cesar Rojas & Chris Stainton - Space Captain
Set Intoduction - Bill Murray
06. Buddy Guy with Jonny Lang & Ronnie Wood - Five Long Years
07. Buddy Guy with Jonny Lang & Ronnie Wood - Miss You
Jeff Beck Introduction - Bill Murray
08. Jeff Beck - Hammerhead
09. Jeff Beck - Nessun Dorma
Eric Clapton Introduction - Bill Murray
10. Eric Clapton - Crossroads
11. Citizen Cope & Eric Clapton - Hands of the Saints
12. Eric Clapton - I Shot The Sheriff
13. Eric Clapton & Jeff Beck - Shake Your Money Maker
14. Eric Clapton & Steve Winwood - Had To Cry Today
15. Eric Clapton & Steve Winwood - Voodoo Chile
16. Eric Clapton & Steve Winwood - Dear Mr. Fantasy
B.B. King Introduction - Bill Murray
17. B.B. King & Ensemble - The Thrill Is Gone